发给老马备查:+ y2 T/ j4 ~* l+ [$ ^
滴水察海(69304838) 15:23:23
# _' U& k3 D. U! m老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱* n2 M: m, i- a6 ?, {! i
吉非替尼和S-1连用的依据1 l7 J- B: P0 _- `/ G E
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.& v1 L% B, Q. ~3 V7 q# j7 g" \
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
3 L7 h) P; z6 ?3 ~这样是不是推理出,耐药后,可以用S-1和培美了?
' R7 F) |1 s" f结论:
% J; F8 l& S- n# o如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |