发给老马备查:
& z1 D) _/ A" Y' L! u2 K滴水察海(69304838) 15:23:23; b5 F3 i; j; f
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
# y6 g- F) H" ?/ @吉非替尼和S-1连用的依据
# f9 T! z- t1 Q4 v& [$ FGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
' r, \" j: [# N3 g; T是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
! |$ R5 @5 w" A1 T, k7 F' d* k这样是不是推理出,耐药后,可以用S-1和培美了?
9 r4 c( R( P1 X结论:
; M( f4 B( o# n" o, [; r/ I. P如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |