发给老马备查:
) M w& |6 G% u9 ^1 X% _滴水察海(69304838) 15:23:23
Q- Q' B/ I+ G& K" l老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
3 `- g7 R: N( J3 z吉非替尼和S-1连用的依据
. t9 \0 Y( X2 ~# p. Y! `Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
, ]) O2 \, H! ^+ a! k是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达; F" ^! w5 a: K5 J0 I
这样是不是推理出,耐药后,可以用S-1和培美了?
( H' n# s3 D+ ~$ V& b/ F% s, T结论:) G& q' ~: K8 A- ~6 Z. b4 ?
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |