看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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Currently available feasibility data for possible combination strategies. 6 t8 F/ i/ G" a3 @$ l' e; E
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Combination Feasibility according to preliminary data
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. h/ l8 B1 s: B; kBevacizumab + sorafenib Yes, reduced dose
" [" ~/ O& Y9 k: n' T) F4 oBevacizumab + sunitinib† No
: l6 N I" i- t) s, h0 l7 b) GBevacizumab + temsirolimus Yes 0 D) x, [# i' y" ~0 j" u, N8 T
Bevacizumab + everolimus Yes
2 i3 D* I& \5 E) FSorafenib + sunitinib ?
; F) {7 h% y2 \ m# `' H! FSorafenib + temsirolimus Yes, reduced dose 3 m: ]2 y+ x6 T! D7 a& v( I0 v
Sorafenib + everolimus Yes, reduced dose
0 C+ S! _) A/ G2 B% m( p- O! Q+ V2 `Sunitinib + temsirolimus† No 6 i( |5 ?( V6 }4 D
Sunitinib + everolimus ?
# Z G& G9 Y" M# t: z( Q ^% CTemsirolimus + everolimus ? ; T9 @- T( s) w1 f. ]) ]% h
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! d, M. f' L% T- z" F' H7 P T5 Q†Led to US FDA warning." _" _$ U) c) G" g" Q
?: As yet unattempted combination.8 |, l. f' }; X T# M
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